5 Alternatives to Roundup Safer than Glyphosate

The active ingredient in Roundup, Glyphosate, is classified as “probably carcinogenic to humans” by The International Agency for Research on Cancer. So, what are the safer alternatives to Glyphosate for controlling weeds in your garden, lawn, and yard?

Homemade weed killers such as vinegar and salt are great alternatives to Roundup. Burnout II Weed and Grass Killer contains clove oil and citric acid which are great organic substitutes for Glyphosate for domestic and large-scale weed control. Herbicides containing Glufosinate are also safer options.

5 Best Roundup Alternatives

Organic weed killers are considered non-toxic and non-carcinogenic. My research found that products containing ingredients such as clove oil, citric acid, Diquat, and ammonium nonanoate do not pose the risk of cancer, making them safe options.

Image Product Name Active ingredient Price
Burnout II Weed & Grass Killer Concentrate
Burnout II Weed & Grass Killer Concentrate
  • Organic ingredients (citric acid and clove oil)
  • Kills grass and broadleaf weeds.
Green Gobbler Vinegar Weed & Grass Killer
Green Gobbler Vinegar Weed & Grass Killer
  • Vinegar is a safe and effective non-selective weed killer.
  • It can be used in homemade weed-killer recipes.
Nature’s Avenger Organic Weed Killer Concentrate
Avenger Organic Weed Killer
  • Has a natural active ingredient, d-Limonene, a safe and effective weed killer.
  • Great for controlling weeds in yards and farms.
Finale Herbicide
Finale Herbicide
  • The active ingredient Glufosinate is non-toxic to humans and animals.
  • It has a low soil residual effect.
Nufarm Generic Reward Diquat E-Pro
Generic Reward Diquat E-Pro
  • Diquat is a noncarcinogenic active ingredient.
  • Great contact herbicide for driveways, ponds, and patios.

So I tested all these herbicides to see how effectively they kill weeds. Below, I’ve provided as much information as possible, with evidence of their action.

1. Burnout II Weed & Grass Killer Concentrate

Roundup Alternative - Burnout II Weed and Grass Killer
  • Natural active ingredients: Carylic and capric acids.
  • Burnout kills both grassy and broadleaf weeds.
Burnout II alternative to Roundup

Burnout II contains natural, non-carcinogenic ingredients, including Carylic and Capric Acid, which are just as effective as Roundup. Contact with the foliage resulted in rapid plant destruction and desiccation.

Burnout II kills ragweed, bluegrass, quackgrass, chickweed, oxalis, foxtail, dandelion, plantain, and many other weed killers. Check Burnout II’s label here.

2. Green Gobbler Vinegar Weed & Grass Killer

Glyphosate alternative 1 - Green Gobbler Vinegar Weed Killer - Natural and Organic Weed and Grass Killer
  • Non-toxic alternative to glyphosate
  • Can kill grassy + broadleaf weeds
  • OMRI-certified as a safe herbicide for humans + pets.
  • Kills even stubborn weeds like crabgrass.

My #1 Roundup alternative for small-scale use is vinegar. The acetic acid in vinegar is potent and kills weeds to the root on contact and when absorbed.

You can use vinegar to naturally kill weeds in the lawn, driveways, and garden, though it is only a spot treatment since it is non-selective. Just like Roundup, 20% vinegar weed killer concentrate will desiccate any plant it comes in contact with.

I mixed it with salt to improve its efficacy because I wanted to kill weeds permanently.

List of weeds it vinegar organic weed killer controls: Oxalis, Quackgrass, Crabgrass, Dandelions, Cloverweed, Chickweed, and just about any other weed in the lawn and garden, making it a great alternative to glyphosate.

I’ve done separate tests for killing weeds with salt, and the results were great.

3. Nature’s Avenger Organic Weed Killer Concentrate

Nature's Avenger Organic Weed Killer Concentrate - roundup substitute organic
  • Does not stain concrete and pavers.
  • Very effective natural non-selective weed killer.
  • Fast-acting weed killer (see results in 2 hours).

Avenger is a great alternative you can use instead of Roundup. The active ingredient in this herbicide is citrus oil extracted from oranges, making it a non-toxic option to glyphosate herbicides.

It works by naturally stripping away the waxy plant cuticle, causing it to dehydrate and die. You can use it on your lawn and garden as a spot treatment for stubborn weeds.

Avenger Organic Weed Killer concentrate is a non-selective contact herbicide that kills crabgrass, dandelions, creeping charlie, nutsedge, and many others.

4. Finale Herbicide

Finale Herbicide 11.33% glufosinate-ammonium
  • Active ingredient: glufosinate-ammonium
  • Kills weeds fast and permanently. Results in 1 to 4 days.
  • Low soil residual effect.
  • You can seed or transplant within hours of application.

Finale Herbicide kills chickweed, dandelion, clover, crabgrass, quackgrass, foxtail, barnyard grass, annual bluegrass, goosegrass, etc.

5. Diquat E-Pro

Generic Diquat Roundup Alternative
  • Non-carcinogenic glyphosate alternative for aquatic weed control.
  • Fast-acting post-emergent – results in 2 days.
  • Very good for duckweed and red Azolla weeds in ponds.

Diquat is a contact herbicide that causes desiccation and defoliation to kill and control herbs. This way, it interferes with the photosynthesis of plants and, therefore, the cell membrane functions.

You can also use Diquat to kill weeds in landscapes, ponds, and other aquatic settings. Common effective Diquat brands include Syngenta, Nufarm, and Reward.

Commercial organic herbicides

Commercial landscape weed control involves covering large areas to control weeds. Here are some active ingredients and commercial herbicides that are safe alternatives to Roundup.

Organic herbicideCommercial products
Acetic acidWeed Pharm; GreenGobbler Vinegar Weed Killer
Clove oilBurnout II; Matratech; WeedZap; 
d-limoneneGreenMatch; Avenger Organic Weed Killer
Citric AcidC-Cide
Carylic and Capric AcidBurnout II
Glufosinate ammoniumCheetah® Pro; Roundup Pro
DiquatDiquat Landscape; Reward; Aquatic

Homemade Roundup alternative

You can also make your own DIY weed killer using vinegar, dish soap, and salt. Salt and vinegar quickly desiccate plants by impairting their ability to draw water for cell growth. The weed killer can be used to control weeds in driveways, patios and between crevices just as well as Roundup would.

Here’s how to make a homemade weed killer that works like Glyphosate:

  1. Add half a cup of salt in a gallon of vinegar.
  2. Add two tablespoons of dish soap.
  3. Stir to mix well.
  4. Pour the weed killer into a spray bottle.
  5. Spray the potent solution on weeds everyday until they die.

Glyphosate and Cancer


“The herbicide glyphosate and the insecticides malathion and diazinon were classified as probably carcinogenic to humans (Group 2A).”

If you live in California, you’re probably aware of the warning issued on Glyphosate as a possible cancer-causing chemical.

Is glufosinate safer than Glyphosate?

Glufosinate is found in herbicides as an ammonium salt that occurs naturally. It is a broad-spectrum herbicide that is safer than Glyphosate, as it has not been classified for carcinogenic effects.

Although glyphosate is a highly effective non-selective herbicide, some weeds, such as waterhemp and horseweed, are resistant to it.

Glyphosate is more effective on stubborn weeds such as annual grassy weeds, while glufosinate is more effective on annual broadleaf weeds. It may not be very effective on perennial weeds such as mugwort, bindweed, Bermuda grass, and goldenrod.

Their modes of action differ. Glufosinate is a contact weed killer that is locally systemic, while glyphosate is a fully systemic herbicide. Glyphosate is highly successful as a non-selective weed killer because it is translocated through plant cells and will destroy weeds to the root.


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